Denbufylline
- CAS NO.:57076-71-8
- Empirical Formula: C16H24N4O3
- Molecular Weight: 320.39
- MDL number: MFCD00867152
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:40
What is Denbufylline?
Description
Denbufylline, a xanthine derivative and PDE4 inhibitor, has effects such as vasodilatation of cerebral vessels (Willette et al., 1997) and potent activation of the hypothalamic–pituitary–adrenal axis. PDE4 is one of the cyclic adenosine monophosphate (cAMP)–specic phosphodiesterases whose tissue distribution is important in pathologies related to the central nervous and immune systems. In experimental animals, denbufylline increases adrenocorticotropic hormone (ACTH), circulating corticosterone, luteinizing hormone, corticotrophin-releasing hormone, and cAMP content of the hypothalamic tissue, but is without effect on arginine vasopressin (Kumari et al., 1997). Treves and Korczyn (1999) studied patients with AD, mixed dementia, and VaD treated with denbufylline. No signicant differences were found in comparison with placebo for the treatment of AD or VaD, although patients who received denbufylline tended to improve their cognitive scores.
Chemical properties
White Solid
The Uses of Denbufylline
A cell permeable xanthine derivatvie that acts as a selective inhibitor of phosphodiesterase IV (PDE IV). Possesses bronchodilatory properties. Displays negative inotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea pig ventricle apaillary muscle independently of its PDE inhibitory activity.
The Uses of Denbufylline
Bronchial spasmolysis agent
What are the applications of Application
Denbufylline is a xanthine derivative PDE IV inhibitor
Definition
ChEBI: 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione is an oxopurine.
Properties of Denbufylline
Melting point: | 98-100°C |
Boiling point: | 514.8±56.0 °C(Predicted) |
Density | 1.23±0.1 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | DMSO, Methanol |
form | Solid |
pka | -0.17±0.70(Predicted) |
color | Off-White to Pale Beige |
CAS DataBase Reference | 57076-71-8 |
Safety information for Denbufylline
Computed Descriptors for Denbufylline
New Products
Tubulysin D Tubulysin C Tubulysin B Potassium HMDS (1.0 M in THF) Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 1-(1,1-Difluoroethyl)-2-fluorobenzene tetrahydro-4-methyl-2H-pyran 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 3-Aminocyclobutanone hydrochloride Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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