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HomeProduct name listDehydroevodiamine

Dehydroevodiamine

  • CAS NO.:67909-49-3
  • Empirical Formula: C19H15N3O
  • Molecular Weight: 301.35
  • MDL number: MFCD11656140
  • EINECS: 200-258-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Dehydroevodiamine Structural

What is Dehydroevodiamine?

Chemical properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.

The Uses of Dehydroevodiamine

Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.

Biological Activity

Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.

Physiological effects

Dehydroevodiamine has an antihypertensive and antitumor effects.

in vitro

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.

Western Blot Analysis

Cell Line:

td>
RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR

< td class="col1"> Cell Line: td>
RAW 264.7 macrophage cells
Concentration: 10 μM, 30 μM, 50 μM
Incubation Time: pretreated 2 hours
Result: Reduced iNOS and COX-2 mRNA expression.

Properties of Dehydroevodiamine

Melting point: 190-192℃
storage temp.  2-8°C
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  powder
color  Yellow

Safety information for Dehydroevodiamine

Computed Descriptors for Dehydroevodiamine

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