Dehydroevodiamine

CAS NO.：67909-49-3
Empirical Formula: C19H15N3O
Molecular Weight: 301.35
MDL number: MFCD11656140
EINECS: 200-258-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Dehydroevodiamine?

Chemical properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.

The Uses of Dehydroevodiamine

Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.

Biological Activity

Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.

Physiological effects

Dehydroevodiamine has an antihypertensive and antitumor effects.

in vitro

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.

Western Blot Analysis

Cell Line: td>	RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 expression and increased IκB-α expression.