Dehydrocorydaline

CAS NO.：30045-16-0
Empirical Formula: C22H24NO4
Molecular Weight: 0
MDL number: MFCD00887635
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:12

What is Dehydrocorydaline?

Chemical properties

Yellow needle crystal powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Corydalis Corydalis, Yuanhu.

The Uses of Dehydrocorydaline

Dehydrocordine has analgesic and sedative effects. It was used for content determination/identification/pharmacological experiments, etc.

Definition

ChEBI: Dehydrocorydaline is an alkaloid.

Biological Activity

Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It can enhance p38 MAPK activation and has anti-inflammatory and anti-cancer effects. Also Dehydrocorydaline has potent antimalarial effects and low cytotoxicity (cell viability > 90%), P. falciparum 3D7 strain (IC50=38 nM).

in vitro

Dehydrocorydaline (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline.
Dehydrocorydaline (0-200 μM) dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.
Dehydrocorydaline (0-200 μM) induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9.

in vivo

Dehydrocorydaline manifests a low acute toxicity with an LD ₅₀ of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection. < /p>

Properties of Dehydrocorydaline

Melting point:	170-173℃
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Cryst.
color	Light yellow to yellow
Stability:	Hygroscopic

Safety information for Dehydrocorydaline

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H304:Aspiration hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P280:Wear protective gloves/protective clothing/eye protection/face protection. P331:Do NOT induce vomiting. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool.