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HomeProduct name listDEHYDROABIETYLAMINE

DEHYDROABIETYLAMINE

Synonym(s):1,4a-Dimethyl-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenemethylamine

  • CAS NO.:1446-61-3
  • Empirical Formula: C20H31N
  • Molecular Weight: 285.47
  • MDL number: MFCD06795849
  • EINECS: 215-899-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
DEHYDROABIETYLAMINE Structural

What is DEHYDROABIETYLAMINE?

Chemical properties

clear yellow viscous liquid

The Uses of DEHYDROABIETYLAMINE

Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans.

What are the applications of Application

Leelamine HCl is a weak CB1 receptor agonist and PDK inhibitor

Definition

ChEBI: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine is a diterpenoid.

Biological Activity

CB 1 agonist. Displaces binding of [ 3 H]-SR141716A with an IC 50 value of 2.86 μ M.

Purification Methods

The crude base is purified by converting 2g of base in toluene (3.3mL) into the acetate salt by heating at 65-70o with 0.46g of AcOH, and the crystals are collected and dried (0.96g from two crops, m 141-143o). The acetate salt is dissolved in warm H2O, basified with aqueous NaOH and extracted with *C6H6. The dried extract (MgSO4) is evaporated in vacuum leaving a viscous oil which crystallises and can be distilled. [Gottstein & Cheney J Org Chem 30 2072 1965.] The picrate has m 234-236o (from aqueous MeOH), and the formate has m 147-148o (from heptane). [Beilstein 12 IV 3005.]

Properties of DEHYDROABIETYLAMINE

Melting point: 44.50℃
Boiling point: 417.89°C (rough estimate)
Density  0.963±0.06 g/cm3 (20 ºC 760 Torr)
refractive index  n20/D 1.546(lit.)
Flash point: >230 °F
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Chloroform, DMSO, Methanol
form  White solid.
pka 10.13±0.29(Predicted)
color  Pale Yellow
optical activity [α]20/D +56.1°, c = 2.4 in pyridine
BRN  3084620
CAS DataBase Reference 1446-61-3(CAS DataBase Reference)
EPA Substance Registry System Dehydroabietylamine (1446-61-3)

Safety information for DEHYDROABIETYLAMINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DEHYDROABIETYLAMINE

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