Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listDEHYDROABIETYLAMINE

DEHYDROABIETYLAMINE

Synonym(s):1,4a-Dimethyl-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenemethylamine

  • CAS NO.:1446-61-3
  • Empirical Formula: C20H31N
  • Molecular Weight: 285.47
  • MDL number: MFCD06795849
  • EINECS: 215-899-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 20:13:01
DEHYDROABIETYLAMINE Structural

What is DEHYDROABIETYLAMINE?

Chemical properties

clear yellow viscous liquid

The Uses of DEHYDROABIETYLAMINE

Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans.

What are the applications of Application

Leelamine HCl is a weak CB1 receptor agonist and PDK inhibitor

Definition

ChEBI: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine is a diterpenoid.

Biological Activity

CB 1 agonist. Displaces binding of [ 3 H]-SR141716A with an IC 50 value of 2.86 μ M.

Purification Methods

The crude base is purified by converting 2g of base in toluene (3.3mL) into the acetate salt by heating at 65-70o with 0.46g of AcOH, and the crystals are collected and dried (0.96g from two crops, m 141-143o). The acetate salt is dissolved in warm H2O, basified with aqueous NaOH and extracted with *C6H6. The dried extract (MgSO4) is evaporated in vacuum leaving a viscous oil which crystallises and can be distilled. [Gottstein & Cheney J Org Chem 30 2072 1965.] The picrate has m 234-236o (from aqueous MeOH), and the formate has m 147-148o (from heptane). [Beilstein 12 IV 3005.]

Properties of DEHYDROABIETYLAMINE

Melting point: 44.50℃
Boiling point: 417.89°C (rough estimate)
Density  0.963±0.06 g/cm3 (20 ºC 760 Torr)
refractive index  n20/D 1.546(lit.)
Flash point: >230 °F
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Chloroform, DMSO, Methanol
form  White solid.
pka 10.13±0.29(Predicted)
color  Pale Yellow
optical activity [α]20/D +56.1°, c = 2.4 in pyridine
BRN  3084620
CAS DataBase Reference 1446-61-3(CAS DataBase Reference)
EPA Substance Registry System Dehydroabietylamine (1446-61-3)

Safety information for DEHYDROABIETYLAMINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DEHYDROABIETYLAMINE

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.