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HomeProduct name listD-(-)-MANDELIC ACID BENZYL ESTER

D-(-)-MANDELIC ACID BENZYL ESTER

  • CAS NO.:97415-09-3
  • Empirical Formula: C15H14O3
  • Molecular Weight: 242.27
  • MDL number: MFCD00674031
  • EINECS: 1312995-182-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:01:56
D-(-)-MANDELIC ACID BENZYL ESTER Structural

What is D-(-)-MANDELIC ACID BENZYL ESTER?

Description

(R)-benzyl Mandelate is a synthetic intermediate useful for pharmaceutical synthesis.

The Uses of D-(-)-MANDELIC ACID BENZYL ESTER

D-(-)-Mandelic Acid Benzyl Ester is a useful reagent for the preparation of a pharmaceutical composition for treating atopic dermatitis.

The Uses of D-(-)-MANDELIC ACID BENZYL ESTER

Benzyl (R)-(-)-mandelate can be employed as reactant to synthesize:

  • (S)-α-Hydroxy-N-(2-phenylethyl)benzenepropanamide (α-hydroxyamides) by enzyme catalyzed amidation reaction.
  • Optically pure (R)- monomethyl esters of 3-[(tert-butyldimethylsilyl)oxy]pentanedioic acid, which is employed in the preparation of HMG-CoA reductase inhibitors.
  • O-Ibuprofenylmandelic acid via acylation reaction with optically active ibuprofen and subsequent hydrogenation.
  • Benzyl (R)-2-fluoro-2-phenylacetate via deoxyfluorination of alcohols using AlkylFluor.
It can also be used to prepare HMG-CoA reductase inhibitors.

What are the applications of Application

(R)-benzyl Mandelate is a synthetic intermediate

Properties of D-(-)-MANDELIC ACID BENZYL ESTER

Melting point: 104-107 °C(lit.)
Boiling point: 387℃
Density  1.204
refractive index  -34 ° (C=1, CH3CN)
Flash point: 163℃
storage temp.  Sealed in dry,Room Temperature
solubility  DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
pka 12.15±0.20(Predicted)
form  powder to crystal
color  White to Almost white
optical activity [α]25/D 55°, c = 1 in chloroform
CAS DataBase Reference 97415-09-3

Safety information for D-(-)-MANDELIC ACID BENZYL ESTER

Computed Descriptors for D-(-)-MANDELIC ACID BENZYL ESTER

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