CYTOCHALASIN J
- CAS NO.:53760-20-6
- Empirical Formula: C28H37NO4
- Molecular Weight: 451.6
- MDL number: MFCD00077708
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is CYTOCHALASIN J?
The Uses of CYTOCHALASIN J
Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research.
What are the applications of Application
Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research
Biological Activity
cytochalasin j can alter mitotic spindle microtubule organization and kinetochore structure.the cytochalasins are cell-permeable fungal metabolites inhibiting actin polymerization, which can alter diverse processes including cell movement, growth, phagocytosis, degranulation, and secretion.
in vitro
cytochalasin j was identified as a deacetylated analog of cytochalasin h that weakly inhibited actin assembly but significantly altered mitotic spindle microtubule organization and kinetochore structure [1]. in a previous study, cytochalasin j treatment of prometaphase cells reduced the number of kmts and the size and organization of the kinetochore lamina. moreover, in approximately 30% of cells treated with cytochalasin j, the failure of a small number of chromosomes to attach to spindle fibers could be documented. these chromosomes showed a significant change in the organization of the kinetochore laminae. light microscopic analyses of cells treated with cytochalasin j revealed loss of chromosome congression, with chromsomes usually located at the periphery of the spindle. cells treated with 10 microg/ml cytochalasin j for 10 min and released into tissue culture medium showed a resumption of chromosome motion within a few minutes, both during congression and anaphase [2].
storage
+4°C
References
[1] walling, e. a.,krafft, g.a. and ware, b.r. actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. archives of biochemistry and biophysics 264(1), 321-332 (1988).
[2] wrench, g. a. and snyder, j.a. cytochalasin j treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in ptk1 cells. cell motility and the cytoskeleton 36(2), 112-124 (1997).
Properties of CYTOCHALASIN J
Melting point: | 138°C (dec.) |
Boiling point: | 679.5±55.0 °C(Predicted) |
Density | 1.20±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide |
form | white lyophilisate |
pka | 13.03±0.70(Predicted) |
color | White |
Stability: | Light Sensitive |
Safety information for CYTOCHALASIN J
Computed Descriptors for CYTOCHALASIN J
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