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HomeProduct name listcycrimine hydrochloride

cycrimine hydrochloride

  • CAS NO.:126-02-3
  • Empirical Formula: C19H29NO.ClH
  • Molecular Weight: 0
  • MDL number: MFCD01700234
  • EINECS: 2047648
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
cycrimine hydrochloride Structural

What is cycrimine hydrochloride?

Originator

Pagitane,Lilly,US,1953

The Uses of cycrimine hydrochloride

Cycrimine Hydrochloride is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.

Definition

ChEBI: The hydrochloride salt of cycrimine. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease.

Manufacturing Process

The manufacture of the cyclohexyl analog is as follows. Phenyl magnesium bromide was prepared from 48.5 g (0.308 mol) of bromobenzene, 7 g (0.29 mol) of magnesium, and 125 ml of dry ether. To it was added at 5°C over a period of ? hour 40 g (0.18 mol) of cyclohexyl β-(N-piperidyl)-ethyl ketone (BP 115° to 117°C/1 mm) in 125 ml of dry ether. The mixture was allowed slowly to come to room temperature, refluxed for one hour, and then poured into ice containing 80 ml of concentrated hydrochloric acid. Ammonium chloride (100 g) and 200 ml of concentrated ammonium hydroxide were added and the organic layer was separated. After drying and removing the solvent, the residue was distilled under reduced pressure. The base distilled at 158° to 170°C (1 mm) and solidified. Upon recrystallization from methanol it melted at 112° to 113°C.

brand name

Pagitane (Lilly).

Therapeutic Function

Muscle relaxant, Antiparkinsonian

Properties of cycrimine hydrochloride

Melting point: 239 - 241°C
storage temp.  -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form  Solid
color  White

Safety information for cycrimine hydrochloride

Computed Descriptors for cycrimine hydrochloride

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