Cyclopropanecarboxaldehyde
- CAS NO.:1489-69-6
- Empirical Formula: C4H6O
- Molecular Weight: 70.09
- MDL number: MFCD00012261
- EINECS: 620-777-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-24 17:21:45
What is Cyclopropanecarboxaldehyde?
Chemical properties
clear colorless liquid
The Uses of Cyclopropanecarboxaldehyde
Cyclopropanecarboxaldehyde reacts with Grignard or organolithium reagents to give the expected secondary alcohols. These are susceptible to ring opening in the presence of HBr, providing stereoselective access to homoallylic bromides. It is also used in the synthesis of eta(2)-enonenickel complexes by reacting with [Ni(cod)(2)] (cod = 1,5-cyclooctadiene) and PBu(3) and to prepare a cyclopropylidene tetralone which underwent an enantioselective palladium-catalyzed [3+2] TMM cycloaddition providing a chiral spiro-fused cyclopentene.
What are the applications of Application
Cyclopropanecarboxaldehyde is a reagent in the preparation of N-alkylphenylalaninamides of pyridinylphenyland oxobipyridinylamines as human GPR 142 agonists for potential use as anti-diabetic agents and the cytochrome P 450 inhibition.
Preparation
Cyclopropanecarboxaldehyde is prepared by reaction of cyclopropylmethanol. The reaction needs reagent pyridinium chlorochromate and solvent CH2Cl2 with other condition of ambient temperature for 3 hours. The yield is about 60%.
Definition
ChEBI: Cyclopropanecarbaldehyde is an organooxygen compound.
Properties of Cyclopropanecarboxaldehyde
Boiling point: | 98-101 °C (lit.) |
Density | 0.938 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 45 °F |
storage temp. | 2-8°C |
solubility | soluble in Chloroform |
form | clear liquid |
color | Colorless to Light orange to Yellow |
Water Solubility | Soluble in water. |
Sensitive | Air Sensitive |
BRN | 906781 |
Stability: | Volatile |
CAS DataBase Reference | 1489-69-6(CAS DataBase Reference) |
NIST Chemistry Reference | Cyclopropanecarboxaldehyde(1489-69-6) |
EPA Substance Registry System | Cyclopropanecarboxaldehyde (1489-69-6) |
Safety information for Cyclopropanecarboxaldehyde
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H225:Flammable liquids H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cyclopropanecarboxaldehyde
InChIKey | JMYVMOUINOAAPA-UHFFFAOYSA-N |
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