Cyclopropanecarboxylic acid

Synonym(s):CPC-acid

CAS NO.：1759-53-1
Empirical Formula: C4H6O2
Molecular Weight: 86.09
MDL number: MFCD00001287
EINECS: 217-162-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-14 14:09:35

What is Cyclopropanecarboxylic acid?

Chemical properties

clear colourless to light yellow liquid

The Uses of Cyclopropanecarboxylic acid

Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIb inhibitors demonstrating inhibition of HCV replication.

What are the applications of Application

Cyclopropanecarboxylic acid is a substrate for a carnitine conjugate

Definition

ChEBI: Cyclopropanecarboxylic acid is a monocarboxylic acid and a member of cyclopropanes. It is a conjugate acid of a cyclopropanecarboxylate.

Preparation

Cyclopropanecarboxylic acid has been prepared by the hydrolysis of cyclopropyl cyanide, although it is unnecessary to isolate the nitrile; by heating cyclopropanedicarboxylic acid; and by the action of alkali on ethyl γ-chlorobutyrate.7 The last two methods do not appear to be of practical importance. The oxidation of cyclopropyl methyl ketone with sodium hypobromite is reported to be an excellent preparative method for this acid.
Org. Synth. 1944, 24, 36
DOI: 10.15227/orgsyn.024.0036

Properties of Cyclopropanecarboxylic acid

Melting point:	14-17 °C (lit.)
Boiling point:	182-184 °C (lit.)
Density	1.081 g/mL at 25 °C (lit.)
refractive index	n20/D 1.438(lit.)
Flash point:	161 °F
storage temp.	2-8°C
solubility	soluble in Chloroform, Ethyl Acetate
pka	4.83(at 25℃)
form	Liquid
color	Clear colorless to light yellow
PH	3 (10g/l, H2O, 22℃)
BRN	969839
CAS DataBase Reference	1759-53-1(CAS DataBase Reference)
NIST Chemistry Reference	Cyclopropanecarboxylic acid(1759-53-1)
EPA Substance Registry System	Cyclopropanecarboxylic acid (1759-53-1)

Safety information for Cyclopropanecarboxylic acid

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.