CYCLO(ARG-GLY-ASP-D-PHE-VAL)
Synonym(s):Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem;RGDFV Peptide, Cyclic
- CAS NO.：137813-35-5
- Empirical Formula: C26H38N8O7
- Molecular Weight: 574.63
- MDL number: MFCD00274410
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is CYCLO(ARG-GLY-ASP-D-PHE-VAL)?
General Description
Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Biochem/physiol Actions
Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates
Properties of CYCLO(ARG-GLY-ASP-D-PHE-VAL)
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| form | White solid |
| pka | 4.01±0.10(Predicted) |
Safety information for CYCLO(ARG-GLY-ASP-D-PHE-VAL)
Computed Descriptors for CYCLO(ARG-GLY-ASP-D-PHE-VAL)
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
![CYCLO[ASP(OBZ)-D-PHE-MEVAL-ARG(MTR)-GLY]](https://img.chemicalbook.in/StructureFile/ChemBookStructure5/GIF/CB0401472.gif)
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