CYCLO(ARG-GLY-ASP-D-PHE-VAL)
Synonym(s):Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem;RGDFV Peptide, Cyclic
- CAS NO.：137813-35-5
- Empirical Formula: C26H38N8O7
- Molecular Weight: 574.63
- MDL number: MFCD00274410
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is CYCLO(ARG-GLY-ASP-D-PHE-VAL)?
General Description
Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Biochem/physiol Actions
Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates
Properties of CYCLO(ARG-GLY-ASP-D-PHE-VAL)
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| form | White solid |
| pka | 4.01±0.10(Predicted) |
Safety information for CYCLO(ARG-GLY-ASP-D-PHE-VAL)
Computed Descriptors for CYCLO(ARG-GLY-ASP-D-PHE-VAL)
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![CYCLO[ASP(OBZ)-D-PHE-MEVAL-ARG(MTR)-GLY]](https://img.chemicalbook.in/StructureFile/ChemBookStructure5/GIF/CB0401472.gif)
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