CYCLO(-LEU-PRO)
- CAS NO.:2873-36-1
- Empirical Formula: C11H18N2O2
- Molecular Weight: 210.27
- MDL number: MFCD00237617
- EINECS: 220-710-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:20
What is CYCLO(-LEU-PRO)?
Description
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.
Chemical properties
White Solid
The Uses of CYCLO(-LEU-PRO)
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.
What are the applications of Application
Cyclo(-Leu-Pro) is a cyclic dipeptide containing leucine and proline
Definition
ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.
Properties of CYCLO(-LEU-PRO)
Melting point: | 163-165℃ |
Boiling point: | 427.6±34.0 °C(Predicted) |
Density | 1.14 |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.27±0.40(Predicted) |
color | White to Off-White |
Safety information for CYCLO(-LEU-PRO)
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for CYCLO(-LEU-PRO)
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin I Tubulysin G Tubulysin B Tubulysin F 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4-(Benzyloxy)-3-bromophenylacetic Acid Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE 3-Aminocyclobutanone hydrochloride 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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