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CTOP

CTOP Structural

What is CTOP?

The Uses of CTOP

CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.

The Uses of CTOP

CTOP has been used:

  • to study the anxiogenic effects induced by CTOP in mice and rat.
  • to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.
  • to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

General Description

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.

Biochem/physiol Actions

Selective ligand for μ-opioid receptors.

storage

Store at -20°C

Properties of CTOP

Boiling point: 1491.2±65.0 °C(Predicted)
Density  1.42±0.1 g/cm3(Predicted)
RTECS  XO8578200
storage temp.  -20°C
pka 9.90±0.15(Predicted)
form  Powder
Water Solubility  Soluble to 1 mg/ml in water

Safety information for CTOP

Computed Descriptors for CTOP

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