CPNQ
Synonym(s):5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline;B2
- CAS NO.：115687-05-3
- Empirical Formula: C20H17ClN4O3
- Molecular Weight: 396.83
- MDL number: MFCD02039810
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-26 16:58:18
What is CPNQ?
The Uses of CPNQ
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer.
What are the applications of Application
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2)
Definition
ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine.
Biological Activity
Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity.
Properties of CPNQ
| Melting point: | 174-176°C |
| Boiling point: | 645.5±55.0 °C(Predicted) |
| Density | 1.412±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | H2O: insoluble <2mg/mL |
| pka | 2.30±0.29(Predicted) |
| form | solid |
| color | brown |
Safety information for CPNQ
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CPNQ
New Products
4,4-Difluoropiperidine hydrochloride tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin N-Isopropylurea N,N-Dicyclohexylcarbodiimide(DCC) MELDRUMS ACID 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID Magnessium Bis glycinate Zinc ascorbate 1-bromo-2-butyne 2-acetamidophenol 9(10H)-anthracenone Erythrosin B, 4-Piperidinopiperidine 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 2-(benzylamino)acetic acid hydrochloride 4-(tert-Butoxycarbonylamino)but- 2-ynoic acid 3,4-dihydro-2H-benzo[b][1,4]dioxepine 1-Phenyl-1-cycloprppanecarboxylicacidRelated products of tetrahydrofuran
![1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE](https://img.chemicalbook.in/CAS/GIF/92394-00-8.gif)
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