CPNQ
Synonym(s):5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline;B2
- CAS NO.：115687-05-3
- Empirical Formula: C20H17ClN4O3
- Molecular Weight: 396.83
- MDL number: MFCD02039810
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:43:00
What is CPNQ?
The Uses of CPNQ
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer.
What are the applications of Application
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2)
Definition
ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine.
Biological Activity
Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity.
Properties of CPNQ
| Melting point: | 174-176°C |
| Boiling point: | 645.5±55.0 °C(Predicted) |
| Density | 1.412±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | H2O: insoluble <2mg/mL |
| pka | 2.30±0.29(Predicted) |
| form | solid |
| color | brown |
Safety information for CPNQ
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CPNQ
New Products
Tubulysin G Tubulysin C Tubulysin M Tubulysin H Diethyl Aluminium Cyanide (1.0 M in Toluene) Potassium HMDS (1.0 M in THF) 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 3-N-BOC-(S)-AMINO BUTYRONITRILE 3-Aminocyclobutanone hydrochloride 2,2-Difluoropropylamine hydrochloride 4-(Benzyloxy)-3-bromophenylacetic Acid 4,4-DIFLUOROPIPERIDINE 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell (+/-)-6-Acetylamino-2- amino-4, 5, 6, 7-tetrahydro Benzo thiazole 3-(S)-(+)- (-1-carbamoyl-1, 1-diphenylmethyl)- pyrrolidine-L- tartarate Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc BorateRelated products of tetrahydrofuran
![1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE](https://img.chemicalbook.in/CAS/GIF/92394-00-8.gif)
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