CONDURITOL B EPOXIDE
Synonym(s):1,2-Anhydro-myo-inositol;CBE, 1,2-Anhydro-myo-inositol;Conduritol B Epoxide - CAS 6090-95-5 - Calbiochem
- CAS NO.:6090-95-5
- Empirical Formula: C6H10O5
- Molecular Weight: 162.14
- MDL number: MFCD00077326
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-25 16:21:11
What is CONDURITOL B EPOXIDE?
Description
Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4.
Chemical properties
White Crystalline Solid
The Uses of CONDURITOL B EPOXIDE
Conduritol B Epoxide acts on b-glucosidases from widely differing sources to show a loss of enzymic activity: from various Aspergillus species, yeast, snail, sweet almonds, and mammals. The other enzymes that have been found to be covalently inhibited are a- glucosidase from yeast and the sucrase-isomaltase complex from rabbit small intestine.
The Uses of CONDURITOL B EPOXIDE
inhibitor of glucosidases
What are the applications of Application
Conduritol B Epoxide (CBE) is a specific covalent β-glycosidase enzyme inhibitor that results in the accumulation of glucocerebroside.
Definition
ChEBI: 1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It is functionally related to a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol.
General Description
Conduritol B epoxide?(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.
Biochem/physiol Actions
Conduritol B epoxide?(CBE)?is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).
storage
Store at -20°C
References
1) Datta and Radin (1988), Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection;? Biochem. Biophys. Res. Commun., 152 155 2) Radin and Vunnam (1981), Inhibitors of cerebroside metabolism;? Methods Enzymol., 72 673 3) Stephens et al. (1981), Distribution of conduritol B epoxide in the animal model for gaucher’s disease (Gaucher mouse); Biochim. Biophys. Acta, 672 29 4) Newburg et al. (1986), beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell;? Biochim. Biophys. Acta, 877 121
Properties of CONDURITOL B EPOXIDE
Melting point: | 157-159 |
Boiling point: | 360.5±42.0 °C(Predicted) |
Density | 1.925±0.06 g/cm3 (20 ºC 760 Torr) |
storage temp. | 2-8°C |
solubility | Soluble in Water (up to 25 mg/ml) or in DMSO |
pka | 13.08±0.70(Predicted) |
form | White solid |
color | White |
Stability: | Moisture Sensitive |
Safety information for CONDURITOL B EPOXIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for CONDURITOL B EPOXIDE
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