CLORGYLINE HYDROCHLORIDE
Synonym(s):Clorgyline
- CAS NO.:17780-75-5
- Empirical Formula: C13H16Cl3NO
- Molecular Weight: 308.63
- MDL number: MFCD00052012
- EINECS: 241-760-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:01
What is CLORGYLINE HYDROCHLORIDE?
Description
Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-
The Uses of CLORGYLINE HYDROCHLORIDE
Antidepressant;Monoamine oxidase A inhibitor
The Uses of CLORGYLINE HYDROCHLORIDE
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:
- in MAO-A biochemical assay
- to study its effects on the transit of serotonin (5-HT) in the human placenta explants
- to study its effects on human prostate cancer cells
What are the applications of Application
Clorgyline hydrochloride is an inhibitor of MAO-A
Biochem/physiol Actions
MAO-A inhibitor.
References
[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.
Properties of CLORGYLINE HYDROCHLORIDE
storage temp. | 2-8°C |
solubility | ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O |
form | A crystalline solid |
color | White to off-white |
Safety information for CLORGYLINE HYDROCHLORIDE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for CLORGYLINE HYDROCHLORIDE
New Products
Tubulysin A Tubulysin F Tubulysin E Tubulysin C 4-(Benzyloxy)-3-bromophenylacetic Acid 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 1-(1,1-Difluoroethyl)-2-fluorobenzene 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropanol Calcium Sodium Phosphosilicate IH Fuel shell Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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