CIS-ACONITIC ANHYDRIDE

Synonym(s):cis-Propene-1,2,3-tricarboxylic anhydride

CAS NO.：6318-55-4
Empirical Formula: C6H4O5
Molecular Weight: 156.09
MDL number: MFCD00005524
EINECS: 228-663-3
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-30 16:20:48

What is CIS-ACONITIC ANHYDRIDE?

The Uses of CIS-ACONITIC ANHYDRIDE

cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).

Purification Methods

Reflux it in xylene (7.5 parts) for 1hour, then evaporate and recrystallise the residue from *C6H6. Alternatively, reflux it in Ac2O, evaporate and recrystallise from *C6H6. It is sensitive to moisture. [IR: Groth & Dahlén Acta Chem Scand 21 291 1967, Malachowski & Maslowski Chem Ber 61 2523 1928, NMR: Gawron & Mahajan Biochemistry 5 2335 1966.] [Beilstein 18/8 V 530.]

Properties of CIS-ACONITIC ANHYDRIDE

Melting point:	75-78 °C (lit.)
Boiling point:	397.8±25.0 °C(Predicted)
Density	1.621±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	3?+-.0.10(Predicted)
Sensitive	Moisture Sensitive
BRN	127575
CAS DataBase Reference	6318-55-4(CAS DataBase Reference)
EPA Substance Registry System	3-Furanacetic acid, 2,5-dihydro-2,5-dioxo- (6318-55-4)

Safety information for CIS-ACONITIC ANHYDRIDE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.