Cinmethylin
Synonym(s):exo-1-Methyl-4-(1-methylethyl)-2-[(2- methylphenyl)methoxy]-7-oxabicyclo[2.2.1]heptane
- CAS NO.:87818-31-3
- Empirical Formula: C18H26O2
- Molecular Weight: 274.4
- MDL number: MFCD01632785
- EINECS: 402-410-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-25 18:43:21
What is Cinmethylin?
Description
Cinmethylinwas developed by Shell Chemical Company in the early 1980s as a weed control agent for monocotyledonous species. This herbicide controls important grasses such as green foxtail (Setaria viridis) and barnyardgrass (Echinochloa crus-galli) and suppresses the growth of several broadleaf weeds such as prickly sida (Sida spinosa) and velvetleaf (Abutilon theophrasti).
The Uses of Cinmethylin
Cinmethylin is used as pre-emergence grass herbicide. Cinmethylin is member of the cineole eucalyptol family.
Definition
ChEBI: Exo-(+)-cinmethylin is a 1-methyl-2-[(2-methylbenzyl)oxy]-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane that is the exo-(+)-isomer of cinmethylin. It is an enantiomer of an exo-(-)-cinmethylin.
Pharmacology
Cinmethylin is active on several important grasses in rice (Echinochloa spp., Cyperus spp., and Monochoria vaginalis) at rates from 25 to 100 g ai/ha (5). Its chemical and toxicological features (low persistence in environment and low mammalian toxicity) generated a significant level of interest in its use as a rice herbicide.
Metabolic pathway
When rats are administered 14C-cinmethylin orally, the major route of its elimination is via urinary excretion. A complex degradation pattern of cinmethylin is observed and the metabolic pathways involve hydroxylation, oxidation at the benzyl and cineol portions, conjugation with glucuronic acid and glycine, and cleavage of the ether linkage. When rats are administered 14C-cinmethylin by stomach incubation, two minor metabolites are identified as o- (acetoxymethyl)benzoic acid and 9-(acetoxymethyl)-a- carboxycinmethylin.
Properties of Cinmethylin
Melting point: | 25°C |
Boiling point: | 313°C |
Density | d20 1015 kg/m3 |
refractive index | 1.4800 (estimate) |
Flash point: | 147 °C |
storage temp. | 0-6°C |
form | neat |
CAS DataBase Reference | 87818-31-3(CAS DataBase Reference) |
EPA Substance Registry System | Cinmethylin (87818-31-3) |
Safety information for Cinmethylin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H332:Acute toxicity,inhalation H411:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Cinmethylin
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
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