CILAZAPRIL
- CAS NO.：92077-78-6
- Empirical Formula: C22H31N3O5.H2O
- Molecular Weight: 435.51
- MDL number: MFCD01692810
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is CILAZAPRIL?
Description
Cilazapril is a new ACE inhibitor useful in the management of mild to moderate hypertension. Orally administered cilazapril is a prodrug which is de-esterified to its active diacid metabolite cilazprilat. Compared with enalapril and captopril, cilazapril is more potent and longer lasting.
Chemical properties
White or almost white, crystalline powder.
Originator
Hoffmann-LaRoche (Switzerland)
The Uses of CILAZAPRIL
Antihypertensive.
Definition
ChEBI: Cilazapril monohydrate is a hydrate that is the monohydrate of cilazapril. It is used for the treatment of hypertension and heart failure. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It contains a cilazapril.
brand name
Inhibace (Hoffmann-LaRoche).
Properties of CILAZAPRIL
| Melting point: | 98° (dec) |
| alpha | D20 -62.51° (c = 1% in ethanol) |
| storage temp. | Store at -20°C |
| solubility | Slightly soluble in water, freely soluble in methanol and in methylene chloride. |
| form | neat |
| pka | pKa1 3.3; pKa2 6.4(at 25℃) |
| form | Solid |
| color | White to off-white |
Safety information for CILAZAPRIL
Computed Descriptors for CILAZAPRIL
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