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HomeProduct name listCHROMANOL 293B

CHROMANOL 293B

Synonym(s):trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

CHROMANOL 293B Structural

What is CHROMANOL 293B?

Description

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.

The Uses of CHROMANOL 293B

Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

What are the applications of Application

Chromanol 293B is a blocker of the slow delayed rectifier K+ current

Definition

ChEBI: Chromanol 293B is a 1-benzopyran.

General Description

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

Biological Activity

Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).

Biochem/physiol Actions

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

storage

Room temperature

Properties of CHROMANOL 293B

Boiling point: 474.1±55.0 °C(Predicted)
Density  1.33±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: 18 mg/mL
form  solid
pka 12.96±0.60(Predicted)
color  white

Safety information for CHROMANOL 293B

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for CHROMANOL 293B

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