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HomeProduct name list(-)-[3R,4S]-CHROMANOL 293B

(-)-[3R,4S]-CHROMANOL 293B

(-)-[3R,4S]-CHROMANOL 293B Structural

What is (-)-[3R,4S]-CHROMANOL 293B?

What are the applications of Application

(?)-[3R,4S]-Chromanol 293B is a selective inhibitor of the slow component of delayed rectifier K+ current

Definition

ChEBI: Chromanol 293B is a 1-benzopyran.

Biological Activity

Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at hERG channels (IC 50 > 30 μ M).

storage

Room temperature

Properties of (-)-[3R,4S]-CHROMANOL 293B

Melting point: 192 °C
Boiling point: 474.1±55.0 °C(Predicted)
Density  1.33±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  DMSO: 18 mg/mL
form  solid
pka 12.96±0.60(Predicted)
color  white

Safety information for (-)-[3R,4S]-CHROMANOL 293B

Computed Descriptors for (-)-[3R,4S]-CHROMANOL 293B

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