Chonglou Saponin VII

CAS NO.：68124-04-9
Empirical Formula: C51H82O21
Molecular Weight: 1031.2
MDL number: MFCD20260362
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is Chonglou Saponin VII?

Chemical properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

The Uses of Chonglou Saponin VII

Used for content determination/identification/pharmacological experiments, etc.

Biological Activity

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.

Pharmacology

Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.

in vitro

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.

in vivo

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.

Properties of Chonglou Saponin VII

Melting point:	243-245 °C (decomp)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	-20°C, protect from light
solubility	Soluble in methanol;
form	powder
pka	12?+-.0.70(Predicted)
color	White
Water Solubility	sparingly soluble in water