Chlorphenesin carbamate

Originator

Maolate ,Upjohn ,US ,1967

The Uses of Chlorphenesin carbamate

'Muscle relaxant

The Uses of Chlorphenesin carbamate

Maolate is a pharmaceutical compound comprising naproxen.

Definition

ChEBI: The carbamate ester of the primary hydroxy group of chlorphenesin. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

1.0 mol of 3-p-chlorophenoxy-1,2-propanediol (chlorphenesin) is suspended in 1,000 ml of benzene in a 5-liter flask equipped with a dropping funnel, thermometer and stirrer. 1.0 mol of phosgene in 500 ml of cold, dry benzene is then added dropwise over a period of 45 minutes, the resulting mixture being maintained at 30°C until all solid material is dissolved. 1.0 mol of triethylamine is added dropwise and the resulting reaction mixture stirred for 45 minutes at 30°C following the addition. The reaction mixture is then cooled to 5°C and extracted repeatedly with 600 ml portions of cold water to remove the triethylamine hydrochloride.
The benzene fraction, containing the intermediate 3-p-chlorophenoxy-3- hydroxypropyl chlorocarbonate, is added to 600 ml of cold concentrated ammonium hydroxide and the resulting reaction mixture agitated vigorously at 5°C for 7 hours. The crude 3-p-chlorophenoxy-2-hydroxypropylcarbamate solid is then filtered off, dissolved in hot benzene, dried to remove all traces of water, and permitted to crystallize out. Several recrystallirations from solvent mixtures of benzene and toluene, with small amounts of acetone, produced a crystalline white solid in about 65% yield. The product is 3-p-chlorophenoxy- 2-hydroxypropyl carbamate, melting at 89° to 91°C. The chlorphenesin starting material is made by reacting p-chlorophenol with glyceryl monochlorohydrin as noted in US Patent 3,214,336.

brand name

Maolate (Pharmacia & Upjohn).

Therapeutic Function

Muscle relaxant

General Description

Chlorphenesin carbamate,3-(p-chlorophenoxy)-1,2-propanediol 1-carbamate (Maolate),is the p-chloro substituted and 1-carbamate derivativeof the lead compound in the development of this group ofagents, mephenesin. Mephenesin is weakly active and shortlivedbecause of facile metabolism of the primary hydroxylgroup. Carbamylation of this group increases activity. p-Chlorination increases the lipophilicity and seals off thepara position from hydroxylation. Metabolism, still fairlyrapid, involves glucuronidation of the secondary hydroxylgroup. The biological half-life in humans is 3.5 hours.

Metabolism

Not Available