Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listchlorothricin

chlorothricin

chlorothricin Structural

What is chlorothricin?

The Uses of chlorothricin

The tetronic acid, chlorothricin, is an unusual macrocyclic antibiotic from a Streptomyces sp., related to kijanimicin, saccharocarcins, tetrocarcins and versipelostatin. Chlorothricin inhibits cholesterol biosynthesis from mevalonate, and inhibits pyruvate carboxylases purified from rat liver, chicken liver and Azotobacter vinelandii.

The Uses of chlorothricin

Chlorothricin is a spirotetronic acid antibiotic inhibitor of pyruvate carboxylase.

What are the applications of Application

Chlorothricin is a spirotetronic acid antibiotic inhibitor of pyruvate carboxylase

Biological Activity

chlorothricin is a macrolide-type antibiotic.macrolides, a class of natural products belonging to the polyketide class of natural products, consist of a large macrocyclic lactone ring. the lactone rings are oftem 14-, 15-, or 16-membered. some macrolides have been reported to have antibiotic or antifungal activity and are widely used as pharmaceutical drugs.

in vitro

in a previous study, chlorothricin was found to inhibit the reaction catalyzed by pyruvate carboxylase from bacillus stearothermophilus. moreover, with steady-state kinetic measurements, inhibition of the overall reaction was found to be competitive with the allosteric activator of this enzyme, coasac, and non-competitive with respect to both substrates of mgatp and pyruvate. these findings strongly indicated that the site 1conformation of pyruvate carboxylase responsible for the regulation of the overall enzyme activity could be influenced by chlorothricin and coasac in an antagonistic manner [1].

References

[1] schindler pw, zhner h. mode of action of the macrolide-type antibiotic, chlorothricin. kinetic study of the inhibition of pyruvate carboxylase from bacillus stearothermophilus. eur j biochem. 1973 nov 15;39(2):591-600.

Properties of chlorothricin

Melting point: 206-207°
Boiling point: 1050.8±65.0 °C(Predicted)
Density  1.39±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
form  solid
pka pK: 5.01, 7.91(at 25℃)
color  white

Safety information for chlorothricin

Computed Descriptors for chlorothricin

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.