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HomeProduct name listChloropyramine hydrochloride

Chloropyramine hydrochloride

Synonym(s):N-p-Chlorobenzyl-N′,N′-dimethyl-N-(2-pyridyl)ethylenediamine

  • CAS NO.:6170-42-9
  • Empirical Formula: C16H21Cl2N3
  • Molecular Weight: 326.26
  • MDL number: MFCD00079009
  • EINECS: 228-216-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Chloropyramine hydrochloride Structural

What is Chloropyramine hydrochloride?

Originator

Chloropyramine,Vramed

The Uses of Chloropyramine hydrochloride

Chloropyramine hydrochloride is a neurotransmitter related agent for research of drug analysis. Also, it is designed to disrupt the focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) interaction in neuroblastoma.

The Uses of Chloropyramine hydrochloride

synthetic

What are the applications of Application

Chloropyramine hydrochloride is a neurotransmitter related agent for research of drug analysis

Manufacturing Process

A solution comprising 40 parts of 2-bromopyridine, 100 parts of N,N-dimethylN'-(4-chlorobenzyl)ethylenediamine and 100 parts of quinoline is heated at 140-145°C for 5 hours. The oil layer after washing with 30% sodium hydroxide solution is distilled, and the fraction which distills at 142-170°C/1 mm is collected. This oil is converted to the monohydrochloride and recrystallized from a mixture of amyl alcohol and ether. The monohydrochloride salt of N,N-dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl) ethylenediamine is obtained which melts at 167-168.4°C.
N,N-Dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl)ethylenediamine may be prepared by another method:
To a mixture of 100 ml of liquid ammonia and about 80 mg of black iron oxide was added 0.78 g (0.02 atom) of potassium. When all of the potassium had reacted, 3.3 g of N,N-dimethyl-N'-(2-pyridyl)ethylenediamine was added. After the addition of 75 ml of dry toluene the ammonia was removed on the steam bath. To the cooled and stirred mixture was added 4.26 g of p-chlorobenzyl chloride, and the reaction mixture was stirred on the steam bath for 11 hours. It was then filtered and concentrated to an oil. This concentrate was taken up in ether, and the ethereal solution was washed with water, dried over sodium sulfate, and concentrated. Distillation gave 2.96 g of yellow liquid. Treatment of this distillate with an equivalent quantity of hydrogen chloride in absolute alcohol and precipitation by the addition of anhydrous ether gave 2.33 g of the N,N-dimethyl-N'-(4-chlorobenzyl)-N'-(2-pyridyl)ethylenediamine hydrochloride.

Therapeutic Function

Antihistaminic

Properties of Chloropyramine hydrochloride

Melting point: 172-174°
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form  neat
form  Solid
color  White to Off-White
CAS DataBase Reference 6170-42-9(CAS DataBase Reference)

Safety information for Chloropyramine hydrochloride

Computed Descriptors for Chloropyramine hydrochloride

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