Chloromethyl ethyl ether

CAS NO.：3188-13-4
Empirical Formula: C3H7ClO
Molecular Weight: 94.54
MDL number: MFCD00000887
EINECS: 221-687-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:38

What is Chloromethyl ethyl ether?

Chemical properties

clear colorless to pale yellow liquid

The Uses of Chloromethyl ethyl ether

Chloromethyl ethyl ether can be used to prepare:

6-Benzyl-1-(ethoxymethyl)-5-iodopyrimidine-2,4(1H,3H)-dione, a key intermediate in the preparation of MKC-442 analog.
Acylation catalyst for alcohols named 1,3-bis-[(R)-1-(2-naphthyl)ethyl]imidazoliumchloride by reacting with glyoxal-bis-[(R)-1-(2-naphthyl)ethyl]imine.

What are the applications of Application

Chloromethyl ethyl ether is used in the synthesis of HIV-1 reverse transcriptase inhibitiors

General Description

A colorless liquid. Slightly denser than water and insoluble in water. Flash point below 73°F. May be moderately toxic by ingestion, inhalation or skin absorption. Severely irritates skin, eyes and mucous membranes.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Chloromethyl ethyl ether tends to form unstable peroxides when exposed to oxygen or air. These products can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Forms salts with strong acids and addition complexes with Lewis acids. May react violently with strong oxidizing agents. I

Health Hazard

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Properties of Chloromethyl ethyl ether

Melting point:	-104°C
Boiling point:	82 °C(lit.)
Density	1.019 g/mL at 25 °C(lit.)
refractive index	n20/D 1.404(lit.)
Flash point:	67 °F
storage temp.	0-6°C
solubility	Chloroform (Soluble), Ethyl Acetate (Slightly)
form	Liquid
color	Clear colorless to pale yellow
Specific Gravity	1.019
InChI	InChI=1S/C3H7ClO/c1-2-5-3-4/h2-3H2,1H3
CAS DataBase Reference	3188-13-4(CAS DataBase Reference)
NIST Chemistry Reference	Ethane, (chloromethoxy)-(3188-13-4)
EPA Substance Registry System	Ethane, (chloromethoxy)- (3188-13-4)

Safety information for Chloromethyl ethyl ether

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H319:Serious eye damage/eye irritation H351:Carcinogenicity
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P308+P313:IF exposed or concerned: Get medical advice/attention.