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HomeProduct name listChloromethyl chloroformate

Chloromethyl chloroformate

  • CAS NO.:22128-62-7
  • Empirical Formula: C2H2Cl2O2
  • Molecular Weight: 128.94
  • MDL number: MFCD00077688
  • EINECS: 244-793-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 17:06:39
Chloromethyl chloroformate Structural

What is Chloromethyl chloroformate?

Chemical properties

Chloromethyl chloroformate is Clear Colourless Oil

The Uses of Chloromethyl chloroformate

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

The Uses of Chloromethyl chloroformate

Chloromethyl chloroformate is used as a reagent in the synthesis of carbamates and carbonates.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 1808, 1984 DOI: 10.1021/ja00318a042

General Description

Chloromethyl chloroformate is a colorless liquid with a penetrating, irritating odor. Denser than water. Contact may irritate skin, eyes and mucous membranes. Toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.

Air & Water Reactions

Reacts with moisture in air to generate heat and hydrochloric acid fumes [Merck, 11th ed., 1989]. Reacts with water.

Reactivity Profile

CHLOROMETHYLCHLOROFORMATE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Properties of Chloromethyl chloroformate

Melting point: <-20°C
Boiling point: 107-108 °C(lit.)
Density  1.449 g/mL at 20 °C
refractive index  n20/D 1.428
Flash point: 95°C
storage temp.  2-8°C
solubility  Chloroform (Soluble), Methanol (Slightly)
form  clear liquid
color  Colorless to Light yellow to Light orange
Water Solubility  Slightly miscible with water.
Sensitive  Moisture Sensitive
BRN  506426
Stability: Extremely Moisture Sensitive, Hygroscopic
CAS DataBase Reference 22128-62-7(CAS DataBase Reference)
EPA Substance Registry System Carbonochloridic acid, chloromethyl ester (22128-62-7)

Safety information for Chloromethyl chloroformate

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H314:Skin corrosion/irritation
H331:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Chloromethyl chloroformate

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