Methyl 2-iodobenzoate

Synonym(s):Methyl o-iodobenzoate

CAS NO.：610-97-9
Empirical Formula: C8H7IO2
Molecular Weight: 262.04
MDL number: MFCD00016351
EINECS: 210-243-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-24 21:11:45

What is Methyl 2-iodobenzoate?

Chemical properties

CLEAR YELLOW LIQUID

The Uses of Methyl 2-iodobenzoate

Methyl 2-iodobenzoate may be used in the preparation of:

N-substituted 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-ones
methyl diphenylacetylene-2-carboxylate
methyl 2-heptynylphenylbenzoate
(E)-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic acid methyl ester
4-(2-carbomethoxyphenyl)-3-(1-methylethoxy)cyclobut-3-ene-1,2-dione
3-(2-carbomethoxyphenyl)-4-methylcyclobuten-3-ene-1,2-dione 2-(ethylene acetal)

Synthesis Reference(s)

Journal of the American Chemical Society, 93, p. 4845, 1971 DOI: 10.1021/ja00748a030

General Description

Methyl 2-iodobenzoate can be prepared from 2-iodobenzoic acid via esterification. It undergoes cobalt-catalyzed cyclization with aldehydes to form phthalide derivatives. The microbial dihydroxylation of methyl 2-iodobenzoate forms a nonracemic iodocyclohexene carboxylate intermediate. This intermediate forms the precursor for preparing kibdelone C.

Properties of Methyl 2-iodobenzoate

Melting point:	64°C
Boiling point:	149-150 °C/10 mmHg (lit.)
Density	1.784 g/mL at 25 °C (lit.)
refractive index	n20/D 1.604(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Ethyl Acetate (Slightly), Methanol
form	Crystalling or Flaky Powder
color	White
Water Solubility	INSOLUBLE
Sensitive	Light Sensitive
BRN	2206859
Stability:	Light Sensitive
CAS DataBase Reference	610-97-9(CAS DataBase Reference)
NIST Chemistry Reference	Methyl-2-iodobenzoate(610-97-9)
EPA Substance Registry System	Benzoic acid, 2-iodo-, methyl ester (610-97-9)

Safety information for Methyl 2-iodobenzoate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.