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HomeProduct name listchlormerodrin

chlormerodrin

  • CAS NO.:62-37-3
  • Empirical Formula: C5H11ClHgN2O2
  • Molecular Weight: 367.197
  • MDL number: MFCD00025457
  • EINECS: 200-530-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:40
chlormerodrin Structural

What is chlormerodrin?

Toxicity

As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.

Originator

Neohydrin,Lakeside,US,1952

The Uses of chlormerodrin

Chlormerodrin is a sulfhydryl blocking agent; using NK cells, particularly CAR-modified NK cells, for producing induced cellular vesicles (ICVs) loaded with chemotherapeutic agent(s) for cancer therapy.

Indications

Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.

Background

Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.

Definition

ChEBI: Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas.

Manufacturing Process

To a refluxing solution of 100 g of allyl urea and 600 ml of absolute methanol there was added with stirring a suspension of 319 g of mercuric acetate and 600 ml of absolute methanol and 60 ml of glacial acetate acid; complete solution resulted. After 6 hours of refluxing, the solution was cooled and clarified by filtration. To this solution there were added 50 g of sodium chloride and 240 ml of water. After a short time a heavy white precipitate settled out. This precipitate, which was 3-chloromercuri-2-methoxypropylurea, was filtered, washed and dried.

brand name

Mercloran (Parke-Davis); Neohydrin (Marion Merrell Dow).

Therapeutic Function

Diuretic

Pharmacokinetics

Chlormerodrin is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.

Metabolism

Not Available

Properties of chlormerodrin

Melting point: 152-153°
Boiling point: 142°C
form  solid

Safety information for chlormerodrin

Computed Descriptors for chlormerodrin

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