CHELERYTHRINE CHLORIDE
Synonym(s):Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem
- CAS NO.:3895-92-9
- Empirical Formula: C21H18ClNO4
- Molecular Weight: 383.82
- MDL number: MFCD00060717
- EINECS: 223-444-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is CHELERYTHRINE CHLORIDE?
Description
Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-
Chemical properties
yellow to orange solid
The Uses of CHELERYTHRINE CHLORIDE
Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.
What are the applications of Application
Chelerythrine chloride is a potent and selective inhibitor of protein kinase C
General Description
Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.
Properties of CHELERYTHRINE CHLORIDE
Melting point: | 195-205 °C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO: ≥10 mg/mL |
form | powder |
color | yellow to orange |
Stability: | Hygroscopic |
Safety information for CHELERYTHRINE CHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CHELERYTHRINE CHLORIDE
InChIKey | WEEFNMFMNMASJY-UHFFFAOYSA-M |
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