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HomeProduct name listCHELERYTHRINE CHLORIDE

CHELERYTHRINE CHLORIDE

Synonym(s):Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

  • CAS NO.:3895-92-9
  • Empirical Formula: C21H18ClNO4
  • Molecular Weight: 383.82
  • MDL number: MFCD00060717
  • EINECS: 223-444-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
CHELERYTHRINE CHLORIDE Structural

What is CHELERYTHRINE CHLORIDE?

Description

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

Chemical properties

yellow to orange solid

The Uses of CHELERYTHRINE CHLORIDE

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

What are the applications of Application

Chelerythrine chloride is a potent and selective inhibitor of protein kinase C

General Description

Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.

Properties of CHELERYTHRINE CHLORIDE

Melting point: 195-205 °C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO: ≥10 mg/mL
form  powder
color  yellow to orange
Stability: Hygroscopic

Safety information for CHELERYTHRINE CHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CHELERYTHRINE CHLORIDE

InChIKey WEEFNMFMNMASJY-UHFFFAOYSA-M

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