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HomeProduct name listChapso

Chapso

Synonym(s):3-([3-Cholamidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfonate;3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate;CHAPSO - CAS 82473-24-3 - Calbiochem

  • CAS NO.:82473-24-3
  • Empirical Formula: C32H58N2O8S
  • Molecular Weight: 630.88
  • MDL number: MFCD00081079
  • EINECS: 617-338-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
Chapso Structural

What is Chapso?

Chemical properties

Chapso is a white crystalline powder. It is a zwitterionic detergent similar to Chaps, however, Chapso is more soluble and particularly better for the solubilization of integral membrane proteins.

The Uses of Chapso

Chapso is a nondenaturing biological detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.

What are the applications of Application

3-(cholamidopropyl)(dimethylammonio)-2-hydroxy-1-propanesulfonate (CHAPSO) may be used in bicelle preparation for β2-adrenergic receptor reconstitution.
CHAPSO has been used:
in a study to assess the processes of liposome solubilization and reconstitution of two transport proteins
in a study to investigate a novel bicelle system for orienting macromolecules over a wide temperature range
as a mixture with dilauroyl phosphatidylcholine (DLPC) in solid-state nuclear magnetic resonance (NMR) technique to study membrane-associated proteins
A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.

What are the applications of Application

CHAPSO is a unique detergent with high CMC

General Description

CHAPSO is a non-denaturing zwitterionic bile salt derivative, derived from Chaps by the addition of a functional hydroxyl group.

Purification Methods

Dissolve this zwitterionic detergent (~ 60g) in 40% aqueous MeOH and stir it with the mixed-bed ion-exchange resin RG-501 x 8 (100g, Bio-Rad) until the pH of the supernatant is ~ 7. Filter off the resin and evaporate the filtrate to dryness under reduced pressure. Check for homogeneity by TLC on silica gel G in 95% MeOH/5% NH4OH and visualize the spot with iodine vapour (see CHAPS above). [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.]

Properties of Chapso

Melting point: 184-186 °C(lit.)
Density  1.0453 (rough estimate)
refractive index  1.6900 (estimate)
storage temp.  -20°C
solubility  H2O: 10 mg/mL at 20 °C, clear, colorless
form  White solid
color  White crystalline
Odor Odorless
Water Solubility  10 g/l at 20 °C
Merck  13,2052
BRN  5842642
CAS DataBase Reference 82473-24-3(CAS DataBase Reference)

Safety information for Chapso

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Chapso

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