Chapso
Synonym(s):3-([3-Cholamidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfonate;3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate;CHAPSO - CAS 82473-24-3 - Calbiochem
- CAS NO.:82473-24-3
- Empirical Formula: C32H58N2O8S
- Molecular Weight: 630.88
- MDL number: MFCD00081079
- EINECS: 617-338-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 08:52:35
What is Chapso?
Chemical properties
Chapso is a white crystalline powder. It is a zwitterionic detergent similar to Chaps, however, Chapso is more soluble and particularly better for the solubilization of integral membrane proteins.
The Uses of Chapso
Chapso is a nondenaturing biological detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.
What are the applications of Application
3-(cholamidopropyl)(dimethylammonio)-2-hydroxy-1-propanesulfonate (CHAPSO) may be used in bicelle preparation for β2-adrenergic receptor reconstitution.
CHAPSO has been used:
in a study to assess the processes of liposome solubilization and reconstitution of two transport proteins
in a study to investigate a novel bicelle system for orienting macromolecules over a wide temperature range
as a mixture with dilauroyl phosphatidylcholine (DLPC) in solid-state nuclear magnetic resonance (NMR) technique to study membrane-associated proteins
A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.
What are the applications of Application
CHAPSO is a unique detergent with high CMC
General Description
CHAPSO is a non-denaturing zwitterionic bile salt derivative, derived from Chaps by the addition of a functional hydroxyl group.
Purification Methods
Dissolve this zwitterionic detergent (~ 60g) in 40% aqueous MeOH and stir it with the mixed-bed ion-exchange resin RG-501 x 8 (100g, Bio-Rad) until the pH of the supernatant is ~ 7. Filter off the resin and evaporate the filtrate to dryness under reduced pressure. Check for homogeneity by TLC on silica gel G in 95% MeOH/5% NH4OH and visualize the spot with iodine vapour (see CHAPS above). [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.]
Properties of Chapso
Melting point: | 184-186 °C(lit.) |
Density | 1.0453 (rough estimate) |
refractive index | 1.6900 (estimate) |
storage temp. | -20°C |
solubility | H2O: 10 mg/mL at 20 °C, clear, colorless |
form | White solid |
color | White crystalline |
Odor | Odorless |
Water Solubility | 10 g/l at 20 °C |
Merck | 13,2052 |
BRN | 5842642 |
CAS DataBase Reference | 82473-24-3(CAS DataBase Reference) |
Safety information for Chapso
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Chapso
Abamectin manufacturer
Pallav Chemicals And Solvents Pvt Ltd
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