CHAETOGLOBOSIN A
Synonym(s):3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione;4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-
- CAS NO.:50335-03-0
- Empirical Formula: C32H36N2O5
- Molecular Weight: 528.64
- MDL number: MFCD31380758
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is CHAETOGLOBOSIN A?
Description
Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3
Occurrence
A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth in wheat coleoptiles.
The Uses of CHAETOGLOBOSIN A
Chaetoglobosin A is a mycotoxic cytochalasan compound.
What are the applications of Application
Chaetoglobosin A is a mycotoxic cytochalasan compound
Definition
ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.
storage
+4°C
References
1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734 2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289 3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262
Properties of CHAETOGLOBOSIN A
Melting point: | 188°C |
Boiling point: | 608.81°C (rough estimate) |
Density | 1.1705 (rough estimate) |
refractive index | 1.5800 (estimate) |
storage temp. | -20°C |
solubility | DMSO: soluble10mg/mL |
pka | 17.32±0.30(Predicted) |
form | solid |
color | Yellow |
Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
Safety information for CHAETOGLOBOSIN A
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for CHAETOGLOBOSIN A
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