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HomeProduct name listCHAETOGLOBOSIN A

CHAETOGLOBOSIN A

Synonym(s):3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione;4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-

CHAETOGLOBOSIN A Structural

What is CHAETOGLOBOSIN A?

Description

Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3

Occurrence

A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth in wheat coleoptiles.

The Uses of CHAETOGLOBOSIN A

Chaetoglobosin A is a mycotoxic cytochalasan compound.

What are the applications of Application

Chaetoglobosin A is a mycotoxic cytochalasan compound

Definition

ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.

storage

+4°C

References

1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734 2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289 3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262

Properties of CHAETOGLOBOSIN A

Melting point: 188°C
Boiling point: 608.81°C (rough estimate)
Density  1.1705 (rough estimate)
refractive index  1.5800 (estimate)
storage temp.  -20°C
solubility  DMSO: soluble10mg/mL
pka 17.32±0.30(Predicted)
form  solid
color  Yellow
Stability: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety information for CHAETOGLOBOSIN A

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for CHAETOGLOBOSIN A

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