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HomeProduct name listCefcapene pivoxil

Cefcapene pivoxil

  • CAS NO.:105889-45-0
  • Empirical Formula: C23H29N5O8S2
  • Molecular Weight: 567.64
  • MDL number: MFCD00870176
  • EINECS: 1806241-263-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
Cefcapene pivoxil Structural

What is Cefcapene pivoxil?

Description

Flomox was launched in Japan as an orally active cephalosporin for respiratory and urinary tract infections, heptatic infections, ophthalmological and otorhinolarynological infections, skinkoft tissue infections, and for use in gynacology, dentistry and oral surgery. It can be prepared by condesation of 2(Z)-(2-(t-butoxycarbonylamino) thiazol-4-yl)-2-pentenoic acid with 7-amino-3-(carbanoyloxymethyl)- 3-cephem-4-carboxylic acid pivaloyl methyl ester followed by deprotection. Flomox is highly active against a wide variety of Gram-positive and Gram-negative bacteria, except for several strains such as Pseudomonas aeruginosa and enterococci, by acting as a cell wall synthesis inhibitor (β-lactamase stability against TEM-1 type β-lactamases) and is more effective than cefaclor and cefdinir. Absorption is improved by the pivaloyloxymethyl ester group which is easily lost by deesterification during GI absorption to produce the biologically active form. The pivalic acid generated quickly conjugates with carnitine and is excreted in the urine. The drop in plasma levels of carnitine was dose dependent and returned to normal levels upon termination of treatment.

Chemical properties

Off-White Solid

Originator

Shionogi (Japan)

The Uses of Cefcapene pivoxil

Antibacterial. Orally absorbed cephalosporin; ester prodrug of the active free acid metabolite, cefcapene

The Uses of Cefcapene pivoxil

Antibacterial. Orally absorbed cephalosporin; ester prodrug of the active free acid metabolite, Cefcapene.

What are the applications of Application

Cefcapene Pivoxil is Antibacterial and ester prodrug of cefcapene

brand name

Flomox

Properties of Cefcapene pivoxil

Melting point: 158-164°C
Boiling point: 888.4±65.0 °C(Predicted)
Density  1.47±0.1 g/cm3(Predicted)
solubility  DMSO, Water( warm)
form  Solid
pka 11.33±0.60(Predicted)
color  Off-White

Safety information for Cefcapene pivoxil

Computed Descriptors for Cefcapene pivoxil

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