Calcitonin salmon
Synonym(s):Calcitonin, Salmon;Thyrocalcitonin
- CAS NO.:47931-85-1
- Empirical Formula: C145H240N44O48S2
- Molecular Weight: 3431.85
- MDL number: MFCD00133859
- EINECS: 256-342-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Calcitonin salmon?
Description
Calcitonin is a single-chain polypeptide consisting of 32 amino acid residues. Calcitonins as obtained from different species are identical at seven of the first nine residues, contain Gly at position 28, and all terminate with Pro-NH2. The C-terminal proline amide (ProNH2) is very important for the biological function of CT, as is the disulfide bridge between Cys residues at positions 1 and 7. In contrast, the residues from 10 through 27 can be varied and seem to influence CT's potency as well as its duration of action. Salmon CT differs from human CT at 16 amino acid residues.
Chemical properties
White or almost white powder.
The Uses of Calcitonin salmon
Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).
The Uses of Calcitonin salmon
Osteoporosis;Hypercalcemia; Paget’s disease ; Reflex sympathetic dystrophy (algodistrophy or Sudeck’s disease)
What are the applications of Application
Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties
brand name
Calcimar (Rhone- Poulenc Rorer);.
Biochem/physiol Actions
Calcitonin also refers as thyrocalcitonin is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compare to serum. It acts as a first messenger and hence regulate the the production of cAMP as well as mammalian sperm function. It may also facilitate the regulation of different isoforms of adenylyl cyclase. Additionally, salmon calcitonin stimulates the bone formation and inhibits the bone resorption in postmenopausal osteoporotic women.
Clinical Use
Only salmon CT is commercially available for medical use, because on a weight basis, it is approximately 45-fold more potent than human CT. Salmon CT, in parenteral form, is approved for treating Paget's disease of bone (generally seen in older persons; involves increased bone resorption and softening of bones), postmenopausal osteoporosis, and hypercalcemia of malignancy (multiple myeloma or advanced breast carcinoma). Salmon CT also is available in a nasal spray formulation, which is used exclusively in the treatment of postmenopausal osteoporosis.
Veterinary Drugs and Treatments
In small animals, calcitonin has been used as adjunctive therapy to control hypercalcemia. Its use has been limited by expense, availability and resistance development to its effects after several days of treatment.
storage
Store at -20°C
Properties of Calcitonin salmon
Melting point: | >222oC (dec.) |
Density | 1.54±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | 0.05 M acetic acid: 1 mg/mL, clear, colorless |
form | powder |
color | White to Off-White |
Water Solubility | Soluble in water at 1mg/ml |
Merck | 13,1642 |
CAS DataBase Reference | 47931-85-1(CAS DataBase Reference) |
Safety information for Calcitonin salmon
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Computed Descriptors for Calcitonin salmon
InChIKey | IYTKRMFJECGBRF-LXQLIYPUSA-N |
Abamectin manufacturer
Piramal Pharma Solutions
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