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HomeProduct name listCALCINEURIN

CALCINEURIN

  • CAS NO.:90371-51-0
  • Molecular Weight: 0
  • MDL number: MFCD00130697
  • Update Date: 2023-04-23 13:52:06

What is CALCINEURIN?

The Uses of CALCINEURIN

Calcineurin from bovine brain has been used:

  • as a positive control in western blot analysis of oocytes and cumulus cells proteome
  • as a positive control in calmodulin (CaM)-agarose binding assay
  • to test its phosphatase activity in the presence of okadaic acid

General Description

Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain.

Biochem/physiol Actions

Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells.

Properties of CALCINEURIN

storage temp.  −20°C
solubility  H2O: soluble
form  lyophilized powder

Safety information for CALCINEURIN

Computed Descriptors for CALCINEURIN

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