BZ-TYR-4-ABZ-OH
- CAS NO.:37106-97-1
- Empirical Formula: C23H20N2O5
- Molecular Weight: 404.42
- MDL number: MFCD00055768
- EINECS: 253-349-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:11
What is BZ-TYR-4-ABZ-OH?
Originator
PFD Oral Sol,Eisai,Japan,1980
The Uses of BZ-TYR-4-ABZ-OH
Diagnostic aid (pancreas function determination).
Definition
ChEBI: The dipeptide obtained by condensation of N-benzoyl-L-tyrosine with 4-aminobenzoic acid. Used as a noninvasive screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic t erapy, it is given by mouth: the amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.
Manufacturing Process
A mixture was made of L-tyrosine (18.1 g, 0.1 mol) benzoyl chloride (7.0 g,
0.05 mol) and 200 ml anhydrous THF. After stirring at reflux for 2 hours, the
mixture was cooled to room temperature, and the precipitate of tyrosine
hydrochloride filtered off (11 g, 46 meq. Cl-). The THF was evaporated and
the residue extracted with CCl4 (3 X 100 ml at reflux, discarded) and then
dissolved in ethyl acetate (200 ml) filtering off insolubles. The ethyl acetate
solution was evaporated to yield 132 g solid product, MP 159°-162°C (93%).
The tyrosine was recovered (8 g) by neutralization with aqueous alkali, from
the hydrochloride.
A solution was made of N-benzyl-L-tyrosine (5.7 g, 20 mmols) and Nmethylmorpholine (2.04 g, 20 mmols) in 60 ml of THF, at -15°C, and to it was
added ethyl chloroformate (2.08 g, 20 mmols). After 12 minutes, paminobenzoic acid (2.74 g, 20 mmols) dissolved in 25 ml of THF and 0.38 g of
p-toluenesulfonic acid (2 mmols) were added, and the temperature allowed to
rise to 5°C. After 2 hours and forty minutes, the mixture was poured into l
liter of 0.1 N cold HCl, stirred one-half hour, filtered and dried, to give 8,7 g,
MP 192°-223°C. The product was recrystallized from 90 ml methanol and 40
ml water, to give 6 g (74%) of product, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, MP 240°-242°C.
brand name
Chymex (Savage).
Therapeutic Function
Diagnostic aid (pancreatic function)
Properties of BZ-TYR-4-ABZ-OH
Melting point: | 240-242° |
Boiling point: | 526.04°C (rough estimate) |
alpha | D25 +72.3° (c = 1 in DMF) (US 3801562); D25 +87° (c = 1 in DMF) (De Benneville) |
Density | 1.3093 (rough estimate) |
refractive index | 1.6300 (estimate) |
storage temp. | Store at RT. |
solubility | DMSO:250.0(Max Conc. mg/mL);618.17(Max Conc. mM) |
form | Solid |
pka | 4.27±0.10(Predicted) |
color | White to off-white |
Safety information for BZ-TYR-4-ABZ-OH
Computed Descriptors for BZ-TYR-4-ABZ-OH
New Products
2,2-diethoxyethanethioamide (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin F Tubulysin C CYCLOBUTYLAMINE HYDROCHLORIDE 4-Methylenepiperidine HCl tert-Butyl (azetidin-3-yl)carbamate hydrochloride Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2,2-Difluoropropylamine hydrochloride 4,4-DIFLUOROCYCLOHEXYLAMINE HYDROCHLORIDE 3-Iodo-4-methyl-n-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 3-(7-Nitro-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione 5-Nitro-3-(trifluoromethyl)pyridine-2-carbonitrile (S)-2-Amino-N-((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)-3-phenylpropanamide hydrochloride ?(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrile (R)-methyl 2-isocyano-3-(tritylthio)propanoate (R)-methyl 2-formamido-3-(tritylthio)propanoate HYDROCORTISONE ACETATE EP IMPURITY E FUSIDIC ACID EP IMPURITY O / FUSIDIC ACID BP IMPURITY O / 16-DEACETYL FUSIDIC ACID SODIUM SALT Montelukast EP Impurity F | Montelukast USP Related Compound ERelated products of tetrahydrofuran
You may like
-
Bz-tyr-4-abz-oh 95% CAS 37106-97-1View Details
37106-97-1 -
3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylanilineView Details
641571-11-1 -
N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamideView Details
90357-51-0 -
Ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate HydrochlorideView Details
183322-17-0 -
Methyl 5-amino-2-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoateView Details
878782-79-7 -
39856-50-3 5-Bromo-2-nitropyridine 98+View Details
39856-50-3 -
1072-97-5 98+View Details
1072-97-5 -
3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole 98+View Details
131986-28-2