Butyl chloroformate

CAS NO.：592-34-7
Empirical Formula: C5H9ClO2
Molecular Weight: 136.58
MDL number: MFCD00000650
EINECS: 209-750-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is Butyl chloroformate?

Chemical properties

clear liquid

The Uses of Butyl chloroformate

Butyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs.

General Description

A colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids.

Reactivity Profile

Butyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Inhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach.

Flammability and Explosibility

Flammable

Properties of Butyl chloroformate

Melting point:	-70 °C
Boiling point:	142 °C(lit.)
Density	1.074 g/mL at 25 °C(lit.)
vapor pressure	2.42 psi ( 20 °C)
refractive index	n20/D 1.412(lit.)
Flash point:	77 °F
storage temp.	2-8°C
form	Liquid
color	Clear
Water Solubility	DECOMPOSES
Sensitive	Moisture Sensitive
BRN	605635
CAS DataBase Reference	592-34-7(CAS DataBase Reference)
NIST Chemistry Reference	Carbonochloridic acid, butyl ester(592-34-7)
EPA Substance Registry System	n-Butyl chloroformate (592-34-7)

Safety information for Butyl chloroformate

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation H331:Acute toxicity,inhalation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.