BUTEIN
Synonym(s):2ʹ,4ʹ,3,4-Tetrahydroxychalcone;Butein - CAS 487-52-5 - Calbiochem
- CAS NO.:487-52-5
- Empirical Formula: C15H12O5
- Molecular Weight: 272.25
- MDL number: MFCD00017300
- EINECS: 207-659-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is BUTEIN?
Chemical properties
Yellow Solid
The Uses of BUTEIN
Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8. Anti-inflammatory agent
What are the applications of Application
Butein is inhibits the tyrosine kinase activity of the EGF receptor and p60c-src
Definition
ChEBI: A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
General Description
Butein (2′,3,4,4′-tetrahydroxychalcone) is a chalcone and a flavonoid, that is produced in plants. It is a plant polyphenol and a bioactive constituent, that is extracted from the heartwood of?Dalbergia odorifera, Caragana jubata and?Rhus verniciflua?stokes, and the stem bark of cashews (Semecarpus anacardium).
Biochem/physiol Actions
Butein exhibit several pharmacological activities, such as anti-oxidant and anti-inflammatory activity. It stimulates apoptotic cell death of human cervical cancer cells. It has therapeutic potentials for chronic diseases, including liver tuberculosis, obesity, diabetes and hypertension. Butein can repress migration and invasion of bladder, breast and pancreatic cancer cells.
Properties of BUTEIN
Melting point: | 216°C |
Boiling point: | 560.9±50.0 °C(Predicted) |
Density | 1.483±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >50 mg/mL |
form | solid |
pka | 7.44±0.35(Predicted) |
color | yellow |
CAS DataBase Reference | 487-52-5(CAS DataBase Reference) |
Safety information for BUTEIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for BUTEIN
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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