Bromazine Hydrochloride
Synonym(s):Bromodiphenhydramine hydrochloride;Diphenhydramine impurity C (PhEur);2-[(RS)-(4-Bromophenyl)phenylmethoxy]-N,N-dimethylethanamine hydrochloride;2-[(4-Bromophenyl)phenylmethoxy]ethyl(dimethyl)ammonium chloride;2-[(RS)-(4-BROMOPHENYL) PHENYLMETHOXY]-N,NDIMETHYLETHANAMINE HYDROCHLORIDE
- CAS NO.：1808-12-4
- Empirical Formula: C17H21BrClNO
- Molecular Weight: 370.71174
- MDL number: MFCD01727165
- EINECS: 2173109
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Bromazine Hydrochloride?
Description
Bromodiphenhydramine is a histamine H1 receptor antagonist. It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 μg/ml. Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats. It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg.
The Uses of Bromazine Hydrochloride
Antihistaminic.
Definition
ChEBI: The hydrochloride salt of bromazine. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.
brand name
Ambodryl.
General Description
Bromodiphenhydraminehydrochloride, 2-[(4-bromophenyl)-phenylmethoxy]-N, N-dimethylethanamine hydrochloride(Ambodryl Hydrochloride), is a white to pale buff crystallinepowder that is freely soluble in water and in alcohol.Relative to diphenhydramine, bromodiphenhydramine ismore lipid soluble and was twice as effective in protectingagainst the lethal effects of histamine aerosols.
Properties of Bromazine Hydrochloride
| Melting point: | 144-145° |
| storage temp. | Refrigerator |
| solubility | Acetone (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | Pale Yellow |
| BRN | 3754363 |
Safety information for Bromazine Hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Bromazine Hydrochloride
Bromazine Hydrochloride manufacturer
Chemikos Laboratories Pvt Ltd
Clickchem Research LLP
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