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HomeProduct name listBombesin

Bombesin

Synonym(s):pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Bombesin Structural

What is Bombesin?

The Uses of Bombesin

Gut tetradecapeptide with the ability to stimulate release of various hormones

Purification Methods

Purify Bombesin by gel filtration on a small column of Sephadex G-10 and elute with 0.01 M AcOH. This procedure removes lower molecular weight contaminants which are retarded on the column. The procedure should be repeated twice, and the material should now be homogeneous on electrophoresis, and on chromatography it gives a single active spot which is negative to ninhydrin but positive to Cl2 and iodoplatinate reagents. RF on paper chromatography (n-BuOH/pyridine/AcOH/H2O :: 37.5: 25:7.5:30) is 0.55 for Bombesin and 0.65 for Alytin. [Bernardi et al. Experientia Part 1 27 166 1971, Anastasi et al. Part 2 27 873 1971.] The hydrochloride has m 185o(dec) (from EtOH) [] D -20.6o [c 0.65, Me2NCHO/(Me2N)3PO (8:2)]. [For the stimulation of inositol phosphate see Lloyd et al. Biochem J 260 813 1989.]

Properties of Bombesin

Density  1.50±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  0.05 M acetic acid: 20 mg/mL, clear, colorless
pka 13.04±0.46(Predicted)
form  Powder
color  White to off-white
Merck  13,1320
BRN  9611365

Safety information for Bombesin

Computed Descriptors for Bombesin

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