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HomeProduct name listBoc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

  • CAS NO.:486460-00-8
  • Empirical Formula: C15H18F3NO4
  • Molecular Weight: 333.31
  • MDL number: MFCD06659147
  • EINECS: 691-120-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Structural

What is Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid?

Description

Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.

The Uses of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.

Synthesis

(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

Properties of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Melting point: 136-138℃
Boiling point: 443.1±45.0 °C(Predicted)
Density  1.292±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig
form  Solid
pka 4.30±0.10(Predicted)
color  White to Off-White

Safety information for Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Abamectin manufacturer

KARPSCHEM LABORATORIES PVT. LTD.

1Y
Phone:+917249203006
Whatsapp: +91 7249203006
product: 486460-00-8 Sitagliptin Impurity 19 (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5- trifluorophenyl)butanoic acid 96%
Inquiry

Stereokem Pvt Ltd

1Y
Phone:+91-9394224843
Whatsapp: +91-9394224843
product: 3(R)-tert-Butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid 98%
Inquiry

Orgamine Chemicals(I) Pvt Ltd

1Y
Phone:+919820080281
Whatsapp: +91-9820080281
product: 3(R)-tert-Butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid 486460-00-8 98%
Inquiry

Mekong pharmaceuticals pvt ltd

1Y
Phone:+918008212221
Whatsapp: +91- 8008212221
product: 486460-00-8 3(R)-tert-Butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid 98%
Inquiry

Allmpus Laboratories Pvt Ltd

1Y
Phone:+91-9167862134
Whatsapp: +91-9167862134
product: Sitagliptin N-BOC Carboxylic acid 98.62
Inquiry

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