BLEOMYCIN A5 HYDROCHLORIDE
Synonym(s):BLEOCIN Streptomyces verticillus, Sterile-Filtered, Aqueous Solution - CAS 55658-47-4 - Calbiochem;BLEOCIN Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem
- CAS NO.:55658-47-4
- Empirical Formula: C57H90ClN19O21S2
- Molecular Weight: 1477.03
- MDL number: MFCD01740724
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:11
What is BLEOMYCIN A5 HYDROCHLORIDE?
The Uses of BLEOMYCIN A5 HYDROCHLORIDE
Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.
What are the applications of Application
Bleomycin A5 hydrochloride is an antitumor antibiotic which induces apoptosis
Biological Activity
bleomycin a5 is an anticancer chemotherapeutic that binds dna and induces dna cleavage and strand breaks, it is highly toxic. additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. bleomycin may also inhibit thioredoxin reductase.
in vitro
the ic50 of blm alone to the cells was about 2.63 μg/ml. the ic50 of blm was decreased to 1/3.8 and 1/9.5 of 2.63 μg/ml when used in combination with 2.63 μg/ml and 5 μg/ml w-131 [1]. bleomycin a5 induced the activation of a jnk pathway in a dose-dependent manner. after 24h treatment, bleomycin a5 induced dramatic cell death. dapi nuclear staining assay revealed that pd98059 (10 μm) markedly enhanced bleomycin a5-induced apoptosis [2].
in vivo
in the rats, bleomycin a5 induced pulmonary inflammation and fibrosis, increased the levels of malondialdehyde and tumour necrosis factor-α and enhanced accumulation of collagen in the lungs. rolipram administration significantly attenuated these effects [3].
References
[1]. zhang h q, he n g, xue s b. effect of bleomycin a5 with calmodulin inhibitor on the proliferation of s-180 cells in vitro[j]. zhongguo yao li xue bao= acta pharmacologica sinica, 1990, 11(5): 470-473.
[2]. yang l c, yang s h, tai k w, et al. mek inhibition enhances bleomycin a5‐induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities[j]. journal of oral pathology & medicine, 2004, 33(1): 37-45.
[3]. pan j b, hou y h, zhang g j. rolipram attenuates bleomycin a5‐induced pulmonary fibrosis in rats[j]. respirology, 2009, 14(7): 975-982.
Properties of BLEOMYCIN A5 HYDROCHLORIDE
Melting point: | >185°C (dec.) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | Solid |
color | White to Pale Yellow |
Stability: | Hygroscopic |
Safety information for BLEOMYCIN A5 HYDROCHLORIDE
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for BLEOMYCIN A5 HYDROCHLORIDE
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