Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listBISINDOLYLMALEIMIDE I HYDROCHLORIDE

BISINDOLYLMALEIMIDE I HYDROCHLORIDE

Synonym(s):2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Structural

What is BISINDOLYLMALEIMIDE I HYDROCHLORIDE?

Description

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.

The Uses of BISINDOLYLMALEIMIDE I HYDROCHLORIDE

GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.

What are the applications of Application

Bisindolylmaleimide I, HCl is a water soluble inhibitor for all known isoforms of PKC

General Description

GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.

Biochem/physiol Actions

Inhibitor of protein kinase C; potent inhibitor of GSK-3.

Properties of BISINDOLYLMALEIMIDE I HYDROCHLORIDE

storage temp.  2-8°C
solubility  DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form  Orange-red solid
color  Orange to red

Safety information for BISINDOLYLMALEIMIDE I HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for BISINDOLYLMALEIMIDE I HYDROCHLORIDE

Related products of tetrahydrofuran

You may like

  • GF 109203X hydrochloride CAS 176504-36-2
    GF 109203X hydrochloride CAS 176504-36-2
    176504-36-2
    View Details
  • Bisindolylmaleimide I, Hydrochloride CAS 176504-36-2
    Bisindolylmaleimide I, Hydrochloride CAS 176504-36-2
    176504-36-2
    View Details
  • Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate 99%
    Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate 99%
    54094-19-8
    View Details
  • 85-81-4 99%
    85-81-4 99%
    85-81-4
    View Details
  • 208111-98-2 (3aR,4R,5R,6aS)-5-(Benzoyloxy)hexahydro-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten- 1-yl]-2H-cyclopenta[b]furan-2-one 99%
    208111-98-2 (3aR,4R,5R,6aS)-5-(Benzoyloxy)hexahydro-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten- 1-yl]-2H-cyclopenta[b]furan-2-one 99%
    208111-98-2
    View Details
  • 2033-24-1 99%
    2033-24-1 99%
    2033-24-1
    View Details
  • Meldrums acid 2033-24-1 99%
    Meldrums acid 2033-24-1 99%
    2033-24-1
    View Details
  • 2-Aminopyridine 504-29-0 99%
    2-Aminopyridine 504-29-0 99%
    504-29-0
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.