Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

Synonym(s):(A-^taPhos)₂PdCl₂;Pd(amphos)Cl₂

CAS NO.：887919-35-9
Empirical Formula: C32H58Cl2N2P2Pd
Molecular Weight: 710.1
MDL number: MFCD09265123
EINECS: 627-800-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-23 10:25:42

Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) Structural

What is Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)?

Chemical properties

Yellow powder

The Uses of Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium is useful catalyst for the Suzuki Cross-Coupling of dioxolanylethyltrifluorborate and aryl/heteroaryl chlorides.

The Uses of Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

Dichlorobis[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II) is a highly active, air-stable catalyst for Suzuki-Miyaura cross-coupling with aryl halides including 5- and 6-membered heteroaryl chlorides.

What are the applications of Application

Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) is a highly active, air-stable catalyst for Suzuki-Miyaura cross-coupling

Synthesis

To a 500 mL reaction was added 10 g (1,5-cyclooctadiene) palladium dichloride, the reaction flask was replaced with a nitrogen atmosphere,19.6 g of di-tert-butyl-4-dimethylaminophenylphosphine and 200 mL of anhydrous tetrahydrofuran were added. The mixture was stirred at room temperature for 16 hours; There was a solid precipitation; filtration and drying gave a pale yellow powder product bis (di-tert-butyl-4-dimethylaminophenylphosphine) palladium chloride. The yield was 97 percent.

Properties of Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder
color	yellow
Water Solubility	Insoluble in water.
InChI	InChI=1S/2C16H28NP.2ClH.Pd/c21-15(2,3)18(16(4,5)6)14-11-9-13(10-12-14)17(7)8;;;/h29-12H,1-8H3;2*1H;

Safety information for Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

InChIKey	AWOFSUFKCXRJMV-UHFFFAOYSA-N
SMILES	P(C1C=CC(N(C)C)=CC=1)(C(C)(C)C)(C(C)(C)C)[Pd+2]([Cl-])([Cl-])P(C1C=CC(N(C)C)=CC=1)(C(C)(C)C)C(C)(C)C