BIS(2,2,2-TRIFLUOROETHYL) ETHER
Synonym(s):2,2,2-Trifluoroethyl ether;Flurothyl
- CAS NO.:333-36-8
- Empirical Formula: C4H4F6O
- Molecular Weight: 182.06
- MDL number: MFCD00010604
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-26 17:21:34
What is BIS(2,2,2-TRIFLUOROETHYL) ETHER?
Chemical properties
clear colorless liquid
Originator
Indoklon ,Ohio Medical, US ,1964
The Uses of BIS(2,2,2-TRIFLUOROETHYL) ETHER
Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease.
The Uses of BIS(2,2,2-TRIFLUOROETHYL) ETHER
5HT agonist
The Uses of BIS(2,2,2-TRIFLUOROETHYL) ETHER
Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes.
What are the applications of Application
Bis(2,2,2-trifluoroethyl) ether is used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes
Definition
ChEBI: Flurotyl is an ether.
Manufacturing Process
23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p
Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1? hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C).
brand name
Indoklon (Ohmeda).
Therapeutic Function
Central stimulant, Convulsant
Properties of BIS(2,2,2-TRIFLUOROETHYL) ETHER
Melting point: | 25°C |
Boiling point: | 62-63 °C (lit.) |
Density | 1.404 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 35 °F |
storage temp. | Flammables area |
solubility | DMSO : ≥ 125 mg/mL (686.59 mM) |
form | clear liquid |
color | Colorless to Almost colorless |
Specific Gravity | 1.41 |
Merck | 14,4201 |
BRN | 1811927 |
CAS DataBase Reference | 333-36-8(CAS DataBase Reference) |
EPA Substance Registry System | HFE-356mff2 (333-36-8) |
Safety information for BIS(2,2,2-TRIFLUOROETHYL) ETHER
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for BIS(2,2,2-TRIFLUOROETHYL) ETHER
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin E Tubulysin C Potassium HMDS (1.0 M in THF) 4,4-DIFLUOROCYCLOHEXANAMINE 4,4-DIFLUOROPIPERIDINE 2H-Pyran, 4-ethynyltetrahydro- Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 1-(1,1-Difluoroethyl)-2-fluorobenzene (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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