Bis-PEG6-acid
- CAS NO.：119189-70-7
- Empirical Formula: C16H30O10
- Molecular Weight: 382.4
- MDL number: MFCD20926399
- Update Date: 2024-10-23 13:36:13
What is Bis-PEG6-acid?
Description
Bis-PEG6-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
The Uses of Bis-PEG6-acid
Bis-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs
Properties of Bis-PEG6-acid
| Boiling point: | 543.4±50.0 °C(Predicted) |
| Density | 1.194±0.06 g/cm3(Predicted) |
| pka | 3.97±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for Bis-PEG6-acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Bis-PEG6-acid
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