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HomeProduct name listBis-PEG10-acid

Bis-PEG10-acid

  • CAS NO.:1268488-70-5
  • Empirical Formula: C22H42O13
  • Molecular Weight: 514.56
  • MDL number: MFCD11041130
  • Update Date: 2024-10-23 13:36:13
Bis-PEG10-acid Structural

What is Bis-PEG10-acid?

Description

Bis-PEG9-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

The Uses of Bis-PEG10-acid

Bis-??PEG9-??acid is used in the preparation of plasma-stable dimeric inhibitors of PSD-95-NMDA receptor interaction.

Biological Activity

Bis-PEG10-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).

Properties of Bis-PEG10-acid

Boiling point: 630.0±55.0 °C(Predicted)
Density  1.174±0.06 g/cm3(Predicted)
storage temp.  2-8°C
pka 3.97±0.10(Predicted)
form  Solid
color  White to off-white

Safety information for Bis-PEG10-acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Bis-PEG10-acid

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