Betamethasone 21-phosphate disodium
Synonym(s):Betamethasone 21-phosphate disodium;Betamethasone disodium phosphate;Betamethasone sodium phosphate
- CAS NO.：151-73-5
- Empirical Formula: C22H28FNa2O8P
- Molecular Weight: 516.4
- MDL number: MFCD00200361
- EINECS: 205-797-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is Betamethasone 21-phosphate disodium?
Chemical properties
White or almost white powder, very hygroscopic.
The Uses of Betamethasone 21-phosphate disodium
Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.
The Uses of Betamethasone 21-phosphate disodium
Nasal, Ophthalmic, Oral, Parenteral
What are the applications of Application
Betamethasone 21-phosphate sodium salt is an anti-inflammatory agent
Definition
ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.
brand name
Celestone (Schering).
Biochem/physiol Actions
Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.
Safety Profile
Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.
Properties of Betamethasone 21-phosphate disodium
| Melting point: | 206-211°C |
| alpha | +98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis) |
| storage temp. | room temp |
| solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| form | neat |
| form | Solid |
| color | White to Off-White |
| PH | 7.5～9.0(5g/l, 25℃) |
| Merck | 14,1180 |
| Stability: | Hygroscopic |
| EPA Substance Registry System | .beta.-Methasone disodium phosphate (151-73-5) |
Safety information for Betamethasone 21-phosphate disodium
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Betamethasone 21-phosphate disodium
| InChIKey | PLCQGRYPOISRTQ-LWCNAHDDSA-L |
| SMILES | [C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r| |
Betamethasone 21-phosphate disodium manufacturer
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