beta-Cyclodextrin hydrate
Synonym(s):β-Schardinger dextrin;beta-Cyclodextrin hydrate;Cycloheptaamylose;Schardinger β-Dextrin hydrate
- CAS NO.:68168-23-0
- Empirical Formula: C42H70O35
- Molecular Weight: 1134.98
- MDL number: MFCD00150811
- EINECS: 231-493-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-29 14:36:51
What is beta-Cyclodextrin hydrate?
Description
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.
Chemical properties
white crystalline powder
The Uses of beta-Cyclodextrin hydrate
beta-Cyclodextrin hydrate forms clathrates. Produces a water-soluble complex with dansyl chloride for the fluorescent labeling of proteins. It is used in pharmaceutical research, as pharmaceutical intermediates and also as chemical reagents.
General Description
β-cyclodextrin (β-CD), a well-known macrocyclic oligosaccharide member of the CD family, is composed of seven D-glucose units connected via α(1→4) glycosidic bonds. Its ability to form several inclusion complexes with organic as well as inorganic compounds makes it a potential candidate in solid and solution state determinations.
Purification Methods
Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.]
Properties of beta-Cyclodextrin hydrate
Melting point: | >260 °C (dec.)(lit.) |
alpha | 161 º (c=1, H2O 25 ºC) |
storage temp. | Refrigerator |
solubility | Water (Slightly) |
form | Crystalline Powder |
color | White |
optical activity | [α]20/D +142°, c = 1 in H2O (Dry basis) |
Water Solubility | 18.5 g/L (25 ºC) |
Merck | 14,2718 |
BRN | 5915513 |
Safety information for beta-Cyclodextrin hydrate
Computed Descriptors for beta-Cyclodextrin hydrate
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