BERBERINE CHLORIDE
Synonym(s):Berberine;Berberine chloride form;Natural Yellow 18
- CAS NO.:141433-60-5
- Empirical Formula: C20H20ClNO5
- Molecular Weight: 389.83
- MDL number: MFCD00011939
- EINECS: 211-195-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is BERBERINE CHLORIDE?
Description
This alkaloid occurs together with Neprotine (q.v.) in Berberis insignis Hook, B. umbellata Wall and Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng.). It is optically inactive and crystallizes from H2O with 5.5 H2O. It yields crystal_x0002_line salts, e.g. the nitrate, m.p. 265-7°C (dec.); sulphate, m.p. 271-3°C (dec.) and the picrate, m.p. 231°C (dec.). The base also furnishes a methyl ether, m.p. 265°C and on catalytic hydrogenation gives the tetrahydro derivative, m.p. 213-5°C (dec.). The ultraviolet spectrum resembles that of berberine (q.v.). Oxidation with KMn04 in Me2CO gives hemipinic acid, identified as the ethylimide, m.p. 90°C.
The Uses of BERBERINE CHLORIDE
Primarily for the treatment of gastroenteritis, dysentery and other intestinal infections and conjunctivitis, purulent otitis media.
References
Orekhov.,J. Amer. Pharm. Assoc., 30,247, (1941)
Chatterjee., ibid, 33,205,210 (1944)
Properties of BERBERINE CHLORIDE
Melting point: | 204-206 °C (dec.) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
Colour Index | 75160 |
color | Pale Yellow to Yellow |
Water Solubility | Soluble in water. |
Sensitive | Light Sensitive |
Merck | 14,1154 |
BRN | 3836585 |
Stability: | Hygroscopic |
CAS DataBase Reference | 141433-60-5(CAS DataBase Reference) |
Safety information for BERBERINE CHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for BERBERINE CHLORIDE
InChIKey | VKJGBAJNNALVAV-UHFFFAOYSA-M |
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