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HomeProduct name listBERBERINE CHLORIDE

BERBERINE CHLORIDE

Synonym(s):Berberine;Berberine chloride form;Natural Yellow 18

  • CAS NO.:141433-60-5
  • Empirical Formula: C20H20ClNO5
  • Molecular Weight: 389.83
  • MDL number: MFCD00011939
  • EINECS: 211-195-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
BERBERINE CHLORIDE Structural

What is BERBERINE CHLORIDE?

Description

This alkaloid occurs together with Neprotine (q.v.) in Berberis insignis Hook, B. umbellata Wall and Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng.). It is optically inactive and crystallizes from H2O with 5.5 H2O. It yields crystal_x0002_line salts, e.g. the nitrate, m.p. 265-7°C (dec.); sulphate, m.p. 271-3°C (dec.) and the picrate, m.p. 231°C (dec.). The base also furnishes a methyl ether, m.p. 265°C and on catalytic hydrogenation gives the tetrahydro derivative, m.p. 213-5°C (dec.). The ultraviolet spectrum resembles that of berberine (q.v.). Oxidation with KMn04 in Me2CO gives hemipinic acid, identified as the ethylimide, m.p. 90°C.

The Uses of BERBERINE CHLORIDE

Primarily for the treatment of gastroenteritis, dysentery and other intestinal infections and conjunctivitis, purulent otitis media.

References

Orekhov.,J. Amer. Pharm. Assoc., 30,247, (1941)
Chatterjee., ibid, 33,205,210 (1944)

Properties of BERBERINE CHLORIDE

Melting point: 204-206 °C (dec.)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
Colour Index  75160
color  Pale Yellow to Yellow
Water Solubility  Soluble in water.
Sensitive  Light Sensitive
Merck  14,1154
BRN  3836585
Stability: Hygroscopic
CAS DataBase Reference 141433-60-5(CAS DataBase Reference)

Safety information for BERBERINE CHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BERBERINE CHLORIDE

InChIKey VKJGBAJNNALVAV-UHFFFAOYSA-M

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