BENZIODARONE
- CAS NO.:68-90-6
- Empirical Formula: C17H12I2O3
- Molecular Weight: 518.08
- MDL number: MFCD00868246
- EINECS: 200-695-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is BENZIODARONE?
Originator
Amplivix,Sigma-Tau
The Uses of BENZIODARONE
Benziodarone is a uricosuric drug,it is used to effectively to control hyperuricemia in renal transplantation.
Background
Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients .
Definition
ChEBI: Benziodarone is an aromatic ketone.
Manufacturing Process
The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone
(benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce
2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of
Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1-
benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride.
4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3-
benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi,
C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To
this solution is gradually added a slight excess of iodine dissolved in a 25%
aqueous solution of potassium iodide. The resultant solution is acidified with a
20% solution of sodium bisulphite, centrifuged, washed with water and then
recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-
diiodophenyl ketone. MP: 167°C.
Therapeutic Function
Coronary vasodilator, Uricosuric
Safety Profile
A poison bj7 intraperitoneal and intravenous routes. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of I-.
Metabolism
Not Available
Properties of BENZIODARONE
Melting point: | 167° |
Density | 1.9173 (estimate) |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
color | Beige |
Water Solubility | 5.881mg/L(20 ºC) |
CAS DataBase Reference | 68-90-6 |
Safety information for BENZIODARONE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up. |
Computed Descriptors for BENZIODARONE
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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